An update after hearing back from the Technical Support person:

The simplest way to resolve this would be to repair EndNote. Mentioned below are the steps to repair EndNote, Note: Please be sure to close EndNote and all Microsoft Office applications and then repair EndNote.

Now, try using EndNote and check if it works. If the issue continues, please try accessing a sample library to see if it works. To open a sample library navigate to C:\Users\Public\Documents\EndNote\Examples. Here, double click on ‘Sample_Library_X6.  If this happens only with a specific library, then please follow the instructions fromhttp://help.thomson.com/default.asp?portalid=TSC&article=82291 to recover the library

My message back to them:

I have followed the steps you gave me for repairing Endnote. It did not fix the problem completely but possibly improved the situation–I can now open the program. However, when I try to open my library I get an error message that says: “Could not initialize database support”. When I tried to open the sample library following your directions I got an error message that says: " Endnote cannot save or create this file. Make sure the disk you want to save the file on is not full, write-protected or damaged" and then gave me an option to save it under a different name/location.

A follow-up from me a few minutes later:

After sending my previous message I thought to restart my computer. After doing that I opened Endnote and got a message that it couldn’t find a library that I don’t keep on this computer but do occasionally open from an external hard drive. I closed that message and tried to open my active library through the open -> select library menu. I then got the original “Endnote has stopped working” message and had to close the program. I then opened it again, and again got the “could not find library” message as before. This time I tried recovering my active library, however after completing this process and trying to open the recovered version I get the same “Endnote has stopped working” message as before. I then tried opening the sample library following your directions and this time it opened. I then tried to open my active library as well and got the “Endnote has stopped working” message as before.

Hopefully no one else out there is having this problem, but if anyone is I hope this info is helpful!

~Riva